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KMID : 1137820220430030170
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의공학회지
2022 Volume.43 No. 3 p.170 ~ p.176
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Integrated Hybrid Device for High-Efficiency Size-Tunable Particle Separation
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Choo Seung-Hee
Park Ji-On
Kim Tae-Eun
Gang Tae-Gyeoung
An Jun-Seok
Oh Ga-Yeong
Kim Yeo-Jin
Park Kyu-Been
Park Chae-Won
Lee Min-Jeong
Lim Hyun-Jung
Nam Jeong-Hun
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Abstract
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Cell separation from a heterogenous mixture sample is an essential process for downstream analysis in biological, chemical, and clinical applications. This study demonstrates an integrated hybrid device of the viscoelastic focusing in a straight rectangular channel and subsequent size-based separation using acoustophoresis to attain high efficiency and separation tunability. For particle pre-alignment in a viscoelastic fluid, the flow rate higher than 10 μl/ min was required. Surface acoustic wave-based lateral migration of particles with different sizes (13 and 27 μm) was examined at various applied voltages and flow rate conditions. Therefore, the flow rate of 100 μl/min and the applied voltage of 20 Vpp can be used for size-based particle separation.
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KEYWORD
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Hybrid device, Viscoelastic focusing, Surface acoustic wave, Separation
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